LA Chargers v Kansas City Chiefs predictions and betting tips – Can Mahomes open with win in Brazil?

 The 2025 NFL season kicks off with a unique international flavor as the Kansas City Chiefs and the Los Angeles Chargers face off in São Paulo, Brazil. The AFC West rivals, who are no strangers to thrilling matchups, will bring their high-powered offenses to a neutral site for the first time in their history. With all eyes on this highly anticipated opener, the betting world is abuzz with predictions and tips.



The Kansas City Chiefs, coming off a strong 15-2 season but a disappointing Super Bowl loss, are looking to reassert their dominance. They are currently favored by 3 points, a testament to their consistent success under the leadership of Patrick Mahomes and Andy Reid. The Chiefs have won their last seven consecutive matchups against the Chargers, a trend that gives bettors confidence in their ability to secure a victory.

On the other side, the Chargers, revitalized by new head coach Jim Harbaugh, are eager to prove they can compete with the league's elite. While they are the designated home team for the Brazil game, the neutral venue may diminish any home-field advantage. The Chargers have covered the spread in three of their last four meetings with the Chiefs, suggesting that even in a loss, they tend to keep the games close. This makes the Chargers at +3 a very attractive bet for those looking for an underdog with a strong chance to cover.



When it comes to the total points, the line is set at 46.5. Recent history between these two teams suggests a lower-scoring affair. The last three matchups have produced totals of 36, 27, and 25 points, respectively. Both teams boast strong defenses, and the humid conditions in Brazil could also play a factor in slowing down the offenses. This makes the Under a popular and logical choice for many bettors.

Looking at individual player props, there are some intriguing options. For the Chiefs, a popular bet is on Patrick Mahomes to go over his passing yards total, as the model projects him to have a big game, and he has a history of big games against the Chargers. Additionally, with Rashee Rice suspended, new receiver Xavier Worthy is a strong candidate for an Anytime Touchdown. On the Chargers' side, rookie running back Omarion Hampton is expected to see a heavy workload and is a good bet to find the end zone.

Ultimately, the Chiefs are the more experienced team with a proven track record against the Chargers. While the Chargers are a formidable opponent, Mahomes' ability to win on a neutral field and his strong record against the Chargers make the Chiefs the safe bet to open their season with a victory in Brazil.

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